ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: PLoS Med. 2019 Aug 6;16(8):e1002848. doi: 10.1371/journal.pmed.1002848.This systematic review identified 28 randomised trials (n =3976 women) of metformin vs. insulin for treatment for gestational diabetes. Metformin use was associated with lower birth weights (overall mean difference −107.7 g), lower ponderal indices, and lower odds of macros...

Nature. 2021;596(7872):393-7. doi: 10.1038/s41586-021-03779-7.PubMed ID: 34349265Brief summary: This study analysed genome-wide association array (GWAS) data on ~200 000 women of European ancestry to identify 290 separate genetic signals associated with normal variation in age at natural menopause (ANM). Experimental alterations of key identified genes in mouse models confirmed their impac...

To read the full abstract: J Clin Endocrinol Metab. 2018 Feb 1;103(2):649-659A minimum level of energy availability is required for the onset of puberty, whereas increased fat mass has been shown to be associated with precocious onset of puberty1,2. Recent genome-wide association studies have identified several loci for age at menarche also associated with obesity3-5. Whethe...